Senior Scientist, Human Genetics

Company: Takeda Pharmaceutical
Location: Boston
Posted on: November 12, 2024

Job Description:

By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's Privacy Notice and Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.Job DescriptionAbout the role:At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as Senior Scientist, Human Genetics in our Cambridge, Massachusetts office. The Human Genetics team in Takeda Research is responsible for generating impactful insights from human genetics data to advance Takeda's pipeline across Gastrointestinal & Inflammatory diseases, Neurosciences and Oncology disease areas. We are seeking an innovative data scientist with deep knowledge in human genetics and multi-omics to join our team and accelerate drug target discovery.In this critical role, you will lead human genetics projects from ideation to execution, using publicly available and proprietary data, to advance target identification and validation, safety assessment, and patient stratification. This role's responsibilities include 1) key contributions to establishing the Human Genetics group strategy, 2) close collaboration with colleagues in various functions across the organization to drive impact and contribute to go-no go decisions across Takeda's drug discovery and development pipeline, and 3) active contributions to external collaborations to link genetic data to longitudinal phenotypic data from diverse populations. You will be empowered to work closely with disease area leads to identify priorities and design human genetic analyses. This is an amazing opportunity to work in an inclusive and highly collaborative cross-functional workplace driven by one mission: drive the science forward to deliver transformative therapies to patients.How you will contribute:ACCOUNTABILITIES -

• Establish an influential and collaborative role within disease-oriented project teams by leading and actively contributing to the design, analysis and interpretation of genetic studies to inform target identification, safety assessment and population stratification in Gastrointestinal & Inflammatory diseases, Neurosciences.
• Work with a community of statistical geneticists to implement a human genetics roadmap and strategy.
• Work collaboratively with data scientists and data engineering groups to enhance integrative analytic pipelines
• Establish and lead external collaborations to implement emerging technologies and/or interrogate relevant biomedical datasets with in-depth genetic and health informationMinimum Requirements/Qualifications:
  • PhD in computational biology, bioinformatics or similar discipline with 2+ years of postdoctoral experience in human genetics research.
  • Deep experience with GWAS/eQTL/pQTL analyses, fine-mapping and colocalization, Mendelian randomization, WES/WGS sequencing data analyses, and rare variants statistical analyses required.
  • Track record experience analyzing genetic data linked to longitudinal real-world health data from large biobanks (e.g. UK Biobank, FINNGEN, Genes and Health, All Of Us, Million Veterans Project etc) required
  • Experience contributing to pre-competitive academic-pharma partnerships preferred.
  • Experience with proteomics (e.g - Olink) and/or transcriptomic data analyses desired.
  • Experience with phenotype ontologies, pathway-based approaches, multivariate analyses, polygenic risk score analyses, machine learning desired.
  • Strong scientific understanding of molecular biology and genomics, and ability to interpret genetic findings in disease context
  • Familiarity with pharmaceutical R&D processes and one or more diseases areas of interest of Takeda (neuroscience, gastrointestinal and inflammation) desired -
  • Excellent communication, presentation and interpersonal skills
  • Independent, highly collaborative with ability to work in cross-functional and diverse team environment
  • Solid knowledge of Unix, command lines interfaces, and fluency in common scripting and/or programming language (e.g. R, Python, Perl, Java, C/C++)
  • Solid experience with parallel computing and cloud computing requiredThis position is currently classified as "hybrid" in accordance with Takeda's Hybrid and Remote Work policy.LOCATION:Cambridge, MA, USA (hybrid)Takeda Compensation and Benefits SummaryWe understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. -For Location:Boston, MAU.S. Base Salary Range:133,000.00 - 209,000.00The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.---The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. -U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation. -EEO StatementTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.LocationsBoston, MAWorker TypeEmployeeWorker Sub-TypeRegularTime TypeFull timeJob ExemptYes

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